ALDH1A1靶向标记分子

Bo, Yang; Zhou, Jingyi; Cai, Kaimin; Wang, Ying; Feng, Yujun; Li, Wenming; Jiang, Yunjiang; Kuo, Shanny Hsuan; Roy, Jarron; Anorma, Chelsea D.; Gardner, Sarah H.; Lau, Gee W.; Bao, Yan; Chan, Jefferson; Wang, Hua; Cheng, Jianjun

ALDH1A1靶向标记分子

精准标记癌干细胞

通过细胞内ALDH1A1酶催化氧化实现对癌干细胞的专一性标记，为后续点击化学药物递送提供靶点。

Bo, Yang · Zhou, Jingyi · Cai, Kaimin · Wang, Ying · Feng, Yujun · Li, Wenming · Jiang, Yunjiang · Kuo, Shanny Hsuan · Roy, Jarron · Anorma, Chelsea D. · Gardner, Sarah H. · Lau, Gee W. · 保研 · Chan, Jefferson · Wang, Hua · Cheng, Jianjun

Proceedings of the National Academy of Sciences of the United States of America 2023

具体参数

肿瘤: ~500 mm³

技术优势

体外和体内选择性标记癌干细胞

与CD44相比，叠氮标记在识别致瘤细胞群体方面更高效