CD8α铰链区增效
采用CD8α铰链区的4-1BB CAR-T细胞在体外和实体瘤异种移植模型中表现出优于CD28和IgG4铰链区的抗肿瘤活性。
Li, Shance · Zhu, Yuge · Xing, Liying · 陆哲明 · 熊宏超 · 张超亭
iScience 2026
CD8α-hinge CAR-T cells exhibited superior activation, cytokine release, and cytotoxicity against Globo-H+ tumor cells in vitro
In xenograft models of renal and ovarian cancer, CD8α-hinge CAR-T cells significantly inhibited tumor growth
enhanced expansion and infiltration into blood and tumor tissues